Juvenile G.P.I.
نویسندگان
چکیده
منابع مشابه
MapReduce in GPI-Space
The computing power of modern high performance systems cannot be fully exploited using traditional parallel programming models. On the other hand, the growing demand for processing big data volumes requires a better control of the workflows, an efficient storage management, as well as a fault-tolerant runtime system. Trying to offer our proper solution to these problems, we designed and develop...
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It is hypothesised that Parkinson’s disease is explained as a change in the pattern of synchronisation of discharges between neurons within the subthalamo-pallidal-thalamo-cortical circuit. By simulating a single GPi neuron receiving non-synchronous and oscillatory inputs the conditions required for the generation of normal and Parkinsonian patterns are determined.
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BACKGROUND Mutations in PMM2 impair phosphomannomutase-2 activity and cause the most frequent congenital disorder of glycosylation, PMM2-CDG. Mannose-1-phosphate, that is deficient in this disorder, is also implicated in the biosynthesis of glycosylphosphatidyl inositol (GPI) anchors. OBJECTIVE To evaluate whether GPI-anchor and GPI-anchored proteins are defective in PMM2-CDG patients. METH...
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To understand the mechanism involved in the apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) we fused to the C-terminus of GFP the GPI-anchor-attachment signal of the folate receptor (FR) or of the prion protein (PrP), two native GPI-anchored proteins that are sorted apically or basolaterally, respectively, in MDCK cells. We investigated the behaviour of the resu...
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In Trypanosoma brucei, glycosylphosphatidylinositol phospholipase C (GPI-PLC) is a virulence factor that releases variant surface glycoprotein (VSG) from dying cells. In live cells, GPI-PLC is localised to the plasma membrane where it is concentrated on the flagellar membrane, so activity or access must be tightly regulated as very little VSG is shed. Little is known about regulation except tha...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1950
ISSN: 0035-9157
DOI: 10.1177/003591575004300401